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Castleman disease

ORPHA:160 · Disease · Disorder

HPO 表現型（共 29 項）

Very frequent (99-80%)(1)

  • LymphadenopathyHP:0002716

Frequent (79-30%)(10)

  • Abdominal painHP:0002027
  • AnemiaHP:0001903
  • Constitutional symptomHP:0025142
  • Elevated circulating C-reactive protein concentrationHP:0011227
  • Elevated erythrocyte sedimentation rateHP:0003565
  • FatigueHP:0012378
  • Follicular hyperplasiaHP:0002729
  • Increased circulating interleukin 6 concentrationHP:0030783
  • Mediastinal lymphadenopathyHP:0100721
  • Weight lossHP:0001824

Occasional (29-5%)(9)

  • Abdominal distentionHP:0003270
  • Abdominal massHP:0031500
  • Abnormality of the gastrointestinal tractHP:0011024
  • CoughHP:0012735
  • Decreased mean corpuscular volumeHP:0025066
  • Flank painHP:0030157
  • Generalized lymphadenopathyHP:0008940
  • JaundiceHP:0000952
  • Nausea and vomitingHP:0002017

Very rare (<4-1%)(9)

  • AnasarcaHP:0012050
  • DyspneaHP:0002094
  • HematuriaHP:0000790
  • Intestinal obstructionHP:0005214
  • MyelofibrosisHP:0011974
  • Renal insufficiencyHP:0000083
  • Restrictive cardiomyopathyHP:0001723
  • ThrombocytopeniaHP:0001873
  • Ureteral obstructionHP:0006000