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Severe hemophilia A

ORPHA:169802 · Clinical subtype · Subtype of disorder

HPO 表現型（共 27 項）

Very frequent (99-80%)(2)

  • Prolonged partial thromboplastin timeHP:0003645
  • Reduced factor VIII activityHP:0003125

Frequent (79-30%)(8)

  • Bruising susceptibilityHP:0000978
  • EpistaxisHP:0000421
  • Joint hemorrhageHP:0005261
  • Joint swellingHP:0001386
  • Oral cavity bleedingHP:0030140
  • Persistent bleeding after traumaHP:0001934
  • Poor wound healingHP:0001058
  • Prolonged bleeding after surgeryHP:0004846

Occasional (29-5%)(17)

  • AnemiaHP:0001903
  • ArthralgiaHP:0002829
  • CephalohematomaHP:0012541
  • Epidural hemorrhageHP:0100310
  • Gastrointestinal hemorrhageHP:0002239
  • HeadacheHP:0002315
  • Intracranial hemorrhageHP:0002170
  • Intramuscular hematomaHP:0012233
  • Limb joint contractureHP:0003121
  • Limitation of joint mobilityHP:0001376
  • Macroscopic hematuriaHP:0012587
  • MenorrhagiaHP:0000132
  • Progressive joint destructionHP:0005187
  • Prolonged bleeding following circumcisionHP:0030137
  • Reduced von Willebrand factor activityHP:0008330
  • Subdural hemorrhageHP:0100309
  • SynovitisHP:0100769