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Moderate hemophilia A

ORPHA:169805 · Clinical subtype · Subtype of disorder

HPO 表現型（共 26 項）

Very frequent (99-80%)(3)

  • Abnormal bleedingHP:0001892
  • Prolonged partial thromboplastin timeHP:0003645
  • Reduced factor VIII activityHP:0003125

Frequent (79-30%)(6)

  • ArthralgiaHP:0002829
  • Bleeding with minor or no traumaHP:0011889
  • Gingival bleedingHP:0000225
  • Intramuscular hematomaHP:0012233
  • Joint hemorrhageHP:0005261
  • Subcutaneous hemorrhageHP:0001933

Occasional (29-5%)(12)

  • ArthropathyHP:0003040
  • Cartilage destructionHP:0100773
  • Gastrointestinal hemorrhageHP:0002239
  • HeadacheHP:0002315
  • HematuriaHP:0000790
  • Intracranial hemorrhageHP:0002170
  • Joint swellingHP:0001386
  • Limitation of joint mobilityHP:0001376
  • Prolonged bleeding after dental extractionHP:0006298
  • Prolonged bleeding after surgeryHP:0004846
  • Subdural hemorrhageHP:0100309
  • SynovitisHP:0100769

Very rare (<4-1%)(5)

  • Epidural hemorrhageHP:0100310
  • Hip contractureHP:0003273
  • Intraventricular hemorrhageHP:0030746
  • SeizureHP:0001250
  • Spontaneous hematomasHP:0007420