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Cushing syndrome due to bilateral macronodular adrenocortical disease
ORPHA:189427 · Disease · Disorder
HPO 表現型（共 39 項）
Obligate (100%)(1)
- Macronodular adrenal hyperplasiaHP:0008231
Very frequent (99-80%)(2)
- Decreased circulating ACTH concentrationHP:0002920
- Moon faciesHP:0500011
Frequent (79-30%)(21)
- Abdominal obesityHP:0012743
- Abnormal libidoHP:0031845
- Abnormal response to corticotropin releasing hormone stimulation testHP:0031077
- Bruising susceptibilityHP:0000978
- DepressionHP:0000716
- Dorsocervical fat padHP:0025383
- Emotional labilityHP:0000712
- Glucose intoleranceHP:0001952
- HirsutismHP:0001007
- HyperlipidemiaHP:0003077
- HypertensionHP:0000822
- Increased circulating cortisol levelHP:0003118
- Increased urinary cortisol levelHP:0012030
- Irregular menstruationHP:0000858
- Kidney stoneHP:0000787
- OsteoporosisHP:0000939
- Paradoxical increased cortisol secretion on dexamethasone suppression testHP:0003466
- PlethoraHP:0001050
- Proximal amyotrophyHP:0007126
- Proximal muscle weaknessHP:0003701
- Striae distensaeHP:0001065
Occasional (29-5%)(8)
- AcneHP:0001061
- AlopeciaHP:0001596
- Hepatic steatosisHP:0001397
- Increased body weightHP:0004324
- Increased susceptibility to fracturesHP:0002659
- ManiaHP:0100754
- Memory impairmentHP:0002354
- Psychotic episodesHP:0000725
Very rare (<4-1%)(7)
- Cognitive impairmentHP:0100543
- Increased circulating aldosterone concentrationHP:0000859
- MeningiomaHP:0002858
- Neuroendocrine neoplasmHP:0100634
- Pituitary adenomaHP:0002893
- Primary hyperparathyroidismHP:0008200
- Renal cell carcinomaHP:0005584