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Immune-mediated necrotizing myopathy

ORPHA:206569 · Disease · Disorder

HPO 表現型（共 24 項）

Very frequent (99-80%)(6)

  • Autoimmune antibody positivityHP:0030057
  • Elevated circulating creatine kinase activityHP:0003236
  • EMG: myopathic abnormalitiesHP:0003458
  • Fatiguable weakness of proximal limb musclesHP:0030200
  • Muscle fiber necrosisHP:0003713
  • MyopathyHP:0003198

Frequent (79-30%)(7)

  • Anti-3-hydroxy- 3-methylglutaryl-coA reductase antibody positivityHP:0033708
  • Anti-signal recognition particle antibody positivityHP:0033713
  • DysphagiaHP:0002015
  • MyalgiaHP:0003326
  • MyositisHP:0100614
  • Proximal lower limb muscle weaknessHP:0008994
  • Skeletal muscle atrophyHP:0003202

Occasional (29-5%)(7)

  • Abnormal pulmonary interstitial morphologyHP:0006530
  • Axial muscle weaknessHP:0003327
  • Chest painHP:0100749
  • MyocarditisHP:0012819
  • NeoplasmHP:0002664
  • PalpitationsHP:0001962
  • Scapular wingingHP:0003691

Very rare (<4-1%)(4)

  • ArthralgiaHP:0002829
  • Congestive heart failureHP:0001635
  • Raynaud phenomenonHP:0030880
  • Skin rashHP:0000988