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Overlap myositis

ORPHA:206572 · Disease · Disorder

HPO 表現型（共 40 項）

Frequent (79-30%)(21)

  • Abnormal circulating lipid concentrationHP:0003119
  • Anti-Ku antibody positivityHP:0034088
  • Anti-PM-Scl antibody positivityHP:0033560
  • Anti-Ro/SS-A antibody positivityHP:0033555
  • Anti-Ro52/TRIM21 antibody positivityHP:0034093
  • Anti-Sm antibody positivityHP:0033040
  • Anti-topoisomerase I antibody positivityHP:0030859
  • Antinuclear antibody positivityHP:0003493
  • ArthritisHP:0001369
  • AutoimmunityHP:0002960
  • Constitutional symptomHP:0025142
  • DysphagiaHP:0002015
  • Elevated circulating creatine kinase activityHP:0003236
  • Finger swellingHP:0025131
  • HypertensionHP:0000822
  • Perifascicular muscle fiber atrophyHP:0100296
  • Proximal muscle weaknessHP:0003701
  • Proximal upper limb muscle weaknessHP:0008997
  • Raynaud phenomenonHP:0030880
  • SclerodactylyHP:0011838
  • Severe infectionHP:0032169

Occasional (29-5%)(18)

  • Abnormal heart morphologyHP:0001627
  • Abnormal pulmonary interstitial morphologyHP:0006530
  • Abnormal skin morphologyHP:0011121
  • Abnormality of connective tissueHP:0003549
  • Abnormality of the kidneyHP:0000077
  • Decreased total leukocyte countHP:0001882
  • Diabetes mellitusHP:0000819
  • Difficulty climbing stairsHP:0003551
  • Distal lower limb muscle weaknessHP:0009053
  • Elevated circulating hepatic transaminase concentrationHP:0002910
  • Gait disturbanceHP:0001288
  • Limb painHP:0009763
  • Pulmonary arterial hypertensionHP:0002092
  • SclerodermaHP:0100324
  • Subluxation of the small joints of the handHP:0004269
  • Systemic lupus erythematosusHP:0002725
  • TetraparesisHP:0002273
  • ThrombocytopeniaHP:0001873

Very rare (<4-1%)(1)

  • Rheumatoid arthritisHP:0001370