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Insulin-resistance syndrome type B

ORPHA:2298 · Disease · Disorder

HPO 表現型（共 50 項）

Very frequent (99-80%)(14)

  • Abnormal circulating fatty acid concentrationHP:0004359
  • Abnormal oral glucose toleranceHP:0004924
  • Acanthosis nigricansHP:0000956
  • AutoimmunityHP:0002960
  • Elevated erythrocyte sedimentation rateHP:0003565
  • Fasting hyperinsulinemiaHP:0008283
  • Glucose intoleranceHP:0001952
  • HyperglycemiaHP:0003074
  • HyperinsulinemiaHP:0000842
  • HypotriglyceridemiaHP:0012153
  • Insulin resistanceHP:0000855
  • Postprandial hyperglycemiaHP:0011998
  • Systemic lupus erythematosusHP:0002725
  • Weight lossHP:0001824

Frequent (79-30%)(19)

  • Abnormal circulating leptin concentrationHP:0004361
  • Abnormal circulating lipid concentrationHP:0003119
  • Abnormality of body weightHP:0004323
  • Antinuclear antibody positivityHP:0003493
  • Decreased body weightHP:0004325
  • Decreased circulating complement factor B concentrationHP:0005416
  • Decreased total leukocyte countHP:0001882
  • Enlarged ovariesHP:0100879
  • Enlarged polycystic ovariesHP:0008675
  • FatigueHP:0012378
  • GlycosuriaHP:0003076
  • HirsutismHP:0001007
  • HypoalbuminemiaHP:0003073
  • Increased serum testosterone levelHP:0030088
  • Insulin-resistant diabetes mellitusHP:0000831
  • NephritisHP:0000123
  • Polycystic ovariesHP:0000147
  • ProteinuriaHP:0000093
  • Type II diabetes mellitusHP:0005978

Occasional (29-5%)(17)

  • Abnormal salivary gland morphologyHP:0010286
  • AlopeciaHP:0001596
  • Biliary cirrhosisHP:0002613
  • Diabetic ketoacidosisHP:0001953
  • Fasting hypoglycemiaHP:0003162
  • Hodgkin lymphomaHP:0012189
  • Hyperinsulinemic hypoglycemiaHP:0000825
  • Increased body weightHP:0004324
  • Increased circulating IgA concentrationHP:0003261
  • Increased circulating IgG concentrationHP:0003237
  • KetosisHP:0001946
  • LymphomaHP:0002665
  • Multiple myelomaHP:0006775
  • OsteoarthritisHP:0002758
  • PneumoniaHP:0002090
  • Skin rashHP:0000988
  • ThrombocytopeniaHP:0001873