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Adrenocortical carcinoma with pure aldosterone hypersecretion

ORPHA:231625 · Disease · Disorder

HPO 表現型（共 18 項）

Obligate (100%)(2)

  • HypertensionHP:0000822
  • Neoplasm of the adrenal glandHP:0100631

Very frequent (99-80%)(6)

  • Decreased circulating renin concentrationHP:0003351
  • Glucocortocoid-insensitive primary hyperaldosteronismHP:0011740
  • HypokalemiaHP:0002900
  • Increased circulating cortisol levelHP:0003118
  • Metabolic alkalosisHP:0200114
  • Muscle weaknessHP:0001324

Frequent (79-30%)(6)

  • Abnormal T-waveHP:0005135
  • Increased urinary potassiumHP:0003081
  • Muscle spasmHP:0003394
  • NauseaHP:0002018
  • PalpitationsHP:0001962
  • ParesthesiaHP:0003401

Occasional (29-5%)(4)

  • EpistaxisHP:0000421
  • HeadacheHP:0002315
  • Intracranial hemorrhageHP:0002170
  • TinnitusHP:0000360