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Progressive supranuclear palsy-corticobasal syndrome

ORPHA:240103 · Clinical subtype · Subtype of disorder

HPO 表現型（共 30 項）

Obligate (100%)(1)

  • BradykinesiaHP:0002067

Very frequent (99-80%)(6)

  • Abnormal pyramidal signHP:0007256
  • ApraxiaHP:0002186
  • Focal dystoniaHP:0004373
  • Limb apraxiaHP:0030217
  • Postural instabilityHP:0002172
  • Slow saccadic eye movementsHP:0000514

Frequent (79-30%)(16)

  • Abnormal saccadic eye movementsHP:0000570
  • AphasiaHP:0002381
  • Diminished movementHP:0002374
  • DysarthriaHP:0001260
  • Frequent fallsHP:0002359
  • Hand clenchingHP:0001188
  • Involuntary movementsHP:0004305
  • Limb myoclonusHP:0045084
  • Memory impairmentHP:0002354
  • Mental deteriorationHP:0001268
  • Progressive extrapyramidal muscular rigidityHP:0007158
  • RigidityHP:0002063
  • Slowed horizontal saccadesHP:0007885
  • Somatic sensory dysfunctionHP:0003474
  • TremorHP:0001337
  • Vertical supranuclear gaze palsyHP:0000511

Occasional (29-5%)(5)

  • DysphagiaHP:0002015
  • Jerky head movementsHP:0006961
  • Parkinsonism with favorable response to dopaminergic medicationHP:0002548
  • Personality changesHP:0000751
  • Speech articulation difficultiesHP:0009088

Very rare (<4-1%)(1)

  • Respiratory distressHP:0002098

Excluded (0%)(1)

  • Frontal release signsHP:0000743