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Subacute sclerosing leukoencephalitis

ORPHA:2806 · Disease · Disorder

HPO 表現型（共 35 項）

Very frequent (99-80%)(3)

  • Atypical behaviorHP:0000708
  • Mental deteriorationHP:0001268
  • MyoclonusHP:0001336

Frequent (79-30%)(20)

  • Abnormal autonomic nervous system physiologyHP:0012332
  • Akinetic mutismHP:0012672
  • Anti-measles antibody positivityHP:0430088
  • Brain atrophyHP:0012444
  • ChorioretinitisHP:0012424
  • DelusionHP:0000746
  • DementiaHP:0000726
  • DepressionHP:0000716
  • DystoniaHP:0001332
  • EEG with periodic complexesHP:0010856
  • Gait disturbanceHP:0001288
  • HallucinationsHP:0000738
  • IrritabilityHP:0000737
  • LethargyHP:0001254
  • Loss of speechHP:0002371
  • Motor regressionHP:0033044
  • Periventricular white matter hyperintensitiesHP:0030891
  • SeizureHP:0001250
  • Sleep disturbanceHP:0002360
  • Vegetative stateHP:0031358

Occasional (29-5%)(12)

  • Abnormal brain choline/creatine ratio by MRSHP:0012709
  • Abnormality of extrapyramidal motor functionHP:0002071
  • AtaxiaHP:0001251
  • CSF oligoclonal immunoglobulin G bandsHP:6000397
  • CSF pleocytosisHP:0012229
  • DyskinesiaHP:0100660
  • PapilledemaHP:0001085
  • Reduced brain N-acetyl aspartate level by MRSHP:0012708
  • Retinal hemorrhageHP:0000573
  • SpasticityHP:0001257
  • VentriculomegalyHP:0002119
  • Visual lossHP:0000572