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POEMS syndrome

ORPHA:2905 · Disease · Disorder

HPO 表現型（共 51 項）

Obligate (100%)(1)

  • PolyneuropathyHP:0001271

Very frequent (99-80%)(6)

  • Abnormal skin physiologyHP:0011122
  • Abnormality of the endocrine systemHP:0000818
  • HypogonadismHP:0000135
  • Increased circulating immunoglobulin concentrationHP:0010702
  • Lymphoproliferative disorderHP:0005523
  • VisceromegalyHP:0003271

Frequent (79-30%)(33)

  • AreflexiaHP:0001284
  • AscitesHP:0001541
  • Clubbing of fingersHP:0100759
  • Diabetes mellitusHP:0000819
  • EdemaHP:0000969
  • Elevated vascular endothelial growth factor levelHP:0031052
  • Erectile dysfunctionHP:0100639
  • FatigueHP:0012378
  • GynecomastiaHP:0000771
  • HemangiomaHP:0001028
  • HepatomegalyHP:0002240
  • Hyperpigmentation of the skinHP:0000953
  • HypertrichosisHP:0000998
  • HypothyroidismHP:0000821
  • LeukonychiaHP:0001820
  • LymphadenopathyHP:0002716
  • Metaphyseal sclerosisHP:0004979
  • Muscle weaknessHP:0001324
  • PainHP:0012531
  • PapilledemaHP:0001085
  • ParesthesiaHP:0003401
  • Pericardial effusionHP:0001698
  • Pleural effusionHP:0002202
  • Primary adrenal insufficiencyHP:0008207
  • Pulmonary arterial hypertensionHP:0002092
  • Sclerosis of foot boneHP:0100925
  • Sclerosis of hand boneHP:0004054
  • Sclerosis of skull baseHP:0002694
  • Sclerotic vertebral endplatesHP:0004576
  • SplenomegalyHP:0001744
  • Thickened skinHP:0001072
  • ThrombocytosisHP:0001894
  • Weight lossHP:0001824

Occasional (29-5%)(11)

  • AcrocyanosisHP:0001063
  • Arterial thrombosisHP:0004420
  • Glomeruloid hemangiomaHP:0031357
  • HyperesthesiaHP:0100963
  • Increased circulating prolactin concentrationHP:0000870
  • LipodystrophyHP:0009125
  • PlethoraHP:0001050
  • PolycythemiaHP:0001901
  • Respiratory insufficiency due to muscle weaknessHP:0002747
  • Restrictive ventilatory defectHP:0002091
  • Venous thrombosisHP:0004936