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Multiple myeloma

ORPHA:29073 · Disease · Disorder

HPO 表現型（共 31 項）

Very frequent (99-80%)(2)

  • OsteopeniaHP:0000938
  • Pathologic fractureHP:0002756

Frequent (79-30%)(13)

  • Acute kidney injuryHP:0001919
  • AnemiaHP:0001903
  • Bone painHP:0002653
  • Decreased circulating immunoglobulin concentrationHP:0004313
  • Elevated circulating creatinine concentrationHP:0003259
  • FatigueHP:0012378
  • Generalized muscle weaknessHP:0003324
  • HyperproteinemiaHP:0002152
  • Increased circulating IgG concentrationHP:0003237
  • NephropathyHP:0000112
  • Nephrotic syndromeHP:0000100
  • OsteolysisHP:0002797
  • PallorHP:0000980

Occasional (29-5%)(13)

  • Abnormal vitamin B12 concentrationHP:0004341
  • Abnormality of the bladderHP:0000014
  • Constrictive median neuropathyHP:0012185
  • Functional abnormality of the gastrointestinal tractHP:0012719
  • HypercalcemiaHP:0003072
  • Increased circulating IgA concentrationHP:0003261
  • KyphosisHP:0002808
  • ParesthesiaHP:0003401
  • Peripheral neuropathyHP:0009830
  • Spinal cord compressionHP:0002176
  • Tall statureHP:0000098
  • Vertebral compression fractureHP:0002953
  • Weight lossHP:0001824

Very rare (<4-1%)(3)

  • LymphadenopathyHP:0002716
  • Pleural effusionHP:0002202
  • SplenomegalyHP:0001744