← 返回搜尋

Wild type ATTR amyloidosis

ORPHA:330001 · Disease · Disorder

HPO 表現型（共 41 項）

Very frequent (99-80%)(9)

  • Abnormal EKGHP:0003115
  • Abnormal pulmonary interstitial morphologyHP:0006530
  • Cardiac transthyretin amyloid depositionHP:0031327
  • Congestive heart failureHP:0001635
  • Left ventricular hypertrophyHP:0001712
  • Myocardial late gadolinium enhancementHP:4000004
  • Pedal edemaHP:0010741
  • Pleural effusionHP:0002202
  • Pulmonary edemaHP:0100598

Frequent (79-30%)(17)

  • Abnormal autonomic nervous system physiologyHP:0012332
  • ArrhythmiaHP:0011675
  • Atrial fibrillationHP:0005110
  • Autonomic bladder dysfunctionHP:0005341
  • Bowel incontinenceHP:0002607
  • Chronic diarrheaHP:0002028
  • Constrictive median neuropathyHP:0012185
  • Decreased QRS voltageHP:0025077
  • Elevated circulating alkaline phosphatase concentrationHP:0003155
  • Elevated circulating NT-proBNP concentrationHP:0031185
  • Gastrointestinal dysmotilityHP:0002579
  • HepatomegalyHP:0002240
  • Impaired vibratory sensationHP:0002495
  • Increased circulating troponin I concentrationHP:0410173
  • Increased circulating troponin T concentrationHP:0410174
  • Intermittent diarrheaHP:0002254
  • Sensory neuropathyHP:0000763

Occasional (29-5%)(15)

  • Abnormal atrioventricular conductionHP:0005150
  • Aortic valve stenosisHP:0001650
  • AscitesHP:0001541
  • BradycardiaHP:0001662
  • HypoesthesiaHP:0033748
  • Myocardial infarctionHP:0001658
  • NephropathyHP:0000112
  • Nephrotic syndromeHP:0000100
  • Orthostatic hypotension due to autonomic dysfunctionHP:0004926
  • Pericardial effusionHP:0001698
  • ProteinuriaHP:0000093
  • Renal insufficiencyHP:0000083
  • Spinal canal stenosisHP:0003416
  • Sudden cardiac deathHP:0001645
  • Weight lossHP:0001824