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Selective IgM deficiency

ORPHA:331235 · Disease · Disorder

HPO 表現型（共 64 項）

Very frequent (99-80%)(4)

  • Decreased circulating IgM concentrationHP:0002850
  • Recurrent infectionsHP:0002719
  • Recurrent respiratory infectionsHP:0002205
  • Severe infectionHP:0032169

Frequent (79-30%)(6)

  • AllergyHP:0012393
  • AutoimmunityHP:0002960
  • Decreased specific antibody response to vaccinationHP:0032140
  • Recurrent pneumoniaHP:0006532
  • Recurrent sinusitisHP:0011108
  • Recurrent upper respiratory tract infectionsHP:0002788

Occasional (29-5%)(38)

  • Allergic rhinitisHP:0003193
  • Antinuclear antibody positivityHP:0003493
  • AsthmaHP:0002099
  • Atopic dermatitisHP:0001047
  • Autoimmune neutropeniaHP:0001904
  • Autoimmune thrombocytopeniaHP:0001973
  • BronchiectasisHP:0002110
  • CellulitisHP:0100658
  • Chronic diarrheaHP:0002028
  • Chronic fatigueHP:0012432
  • Chronic sinusitisHP:0011109
  • Cutaneous abscessHP:0031292
  • Decreased proportion of CD3-positive T cellsHP:0045080
  • Decreased total CD4+ T cell proportionHP:0032218
  • Decreased transitional B cell proportionHP:0030380
  • Growth delayHP:0001510
  • KeratitisHP:0000491
  • LymphadenopathyHP:0002716
  • MeningitisHP:0001287
  • Non-infectious meningitisHP:0033430
  • Nontuberculous mycobacterial pulmonary infectionHP:0032261
  • Otitis mediaHP:0000388
  • ParaproteinemiaHP:0031047
  • PharyngitisHP:0025439
  • Raynaud phenomenonHP:0030880
  • Recurrent bronchitisHP:0002837
  • Recurrent cutaneous fungal infectionsHP:0011370
  • Recurrent herpesHP:0005353
  • Recurrent infection of the gastrointestinal tractHP:0004798
  • Recurrent oral thrushHP:0009098
  • Recurrent staphylococcal infectionsHP:0007499
  • Recurrent urinary tract infectionsHP:0000010
  • Recurrent vulvovaginal candidiasisHP:0012204
  • Rheumatoid arthritisHP:0001370
  • SepsisHP:0100806
  • Severe viral infectionHP:0031691
  • Systemic lupus erythematosusHP:0002725
  • VerrucaeHP:0200043

Very rare (<4-1%)(14)

  • Crohn's diseaseHP:0100280
  • Decreased total CD8+ T cell proportionHP:0005415
  • FasciitisHP:0100537
  • Hashimoto thyroiditisHP:0000872
  • LymphadenitisHP:0002840
  • Multiple myelomaHP:0006775
  • Non-Hodgkin lymphomaHP:0012539
  • Pulmonary tuberculosisHP:0032262
  • Recurrent shinglesHP:0032275
  • Severe varicella zoster infectionHP:0032170
  • Stomach cancerHP:0012126
  • Thyroid carcinomaHP:0002890
  • Tooth abscessHP:0030757
  • Unusual fungal nail infectionHP:0012203

Excluded (0%)(2)

  • Decreased circulating IgA concentrationHP:0002720
  • Decreased circulating IgG concentrationHP:0004315