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African trypanosomiasis

ORPHA:3385 · Disease · Disorder

HPO 表現型（共 86 項）

Very frequent (99-80%)(6)

  • Abnormality of the nervous systemHP:0000707
  • Excessive daytime somnolenceHP:0001262
  • NarcolepsyHP:0030050
  • Periodic feverHP:0032323
  • Sleep disturbanceHP:0002360
  • Sleep-wake cycle disturbanceHP:0006979

Frequent (79-30%)(19)

  • Abnormal basal ganglia MRI signal intensityHP:0012751
  • Abnormal central motor functionHP:0011442
  • Abnormal cerebral white matter morphologyHP:0002500
  • Abnormal EKGHP:0003115
  • Abnormal rapid eye movement sleepHP:0002494
  • ApathyHP:0000741
  • Brain imaging abnormalityHP:0410263
  • FatigueHP:0012378
  • Gait disturbanceHP:0001288
  • HeadacheHP:0002315
  • HepatomegalyHP:0002240
  • HepatosplenomegalyHP:0001433
  • InsomniaHP:0100785
  • LymphadenopathyHP:0002716
  • Muscle weaknessHP:0001324
  • PruritusHP:0000989
  • RigorsHP:0025145
  • SplenomegalyHP:0001744
  • Weight lossHP:0001824

Occasional (29-5%)(47)

  • Abnormal circulating growth hormone concentrationHP:0032367
  • Abnormal prolactin levelHP:0040086
  • Abnormal speech patternHP:0002167
  • Abnormality of circulating cortisol levelHP:0011731
  • Abnormality of renin-angiotensin systemHP:0000847
  • Abnormality of the endocrine systemHP:0000818
  • Abnormality of the menstrual cycleHP:0000140
  • Aggressive behaviorHP:0000718
  • AkinesiaHP:0002304
  • AlopeciaHP:0001596
  • AnxietyHP:0000739
  • ArthralgiaHP:0002829
  • Atypical behaviorHP:0000708
  • ChoreoathetosisHP:0001266
  • ConjunctivitisHP:0000509
  • Cranial nerve paralysisHP:0006824
  • DiarrheaHP:0002014
  • DiplopiaHP:0000651
  • Disseminated intravascular coagulationHP:0005521
  • DyskinesiaHP:0100660
  • FasciculationsHP:0002380
  • GynecomastiaHP:0000771
  • HemiparesisHP:0001269
  • Impaired proprioceptionHP:0010831
  • ImpotenceHP:0000802
  • InfertilityHP:0000789
  • Involuntary movementsHP:0004305
  • IritisHP:0001101
  • IrritabilityHP:0000737
  • JaundiceHP:0000952
  • KeratitisHP:0000491
  • Motor polyneuropathyHP:0007178
  • NauseaHP:0002018
  • Optic neuritisHP:0100653
  • ParalysisHP:0003470
  • ParesthesiaHP:0003401
  • Primitive reflexHP:0002476
  • Psychotic mentationHP:0001345
  • Reduced consciousnessHP:0004372
  • Renal insufficiencyHP:0000083
  • Second degree atrioventricular blockHP:0011706
  • Somatic sensory dysfunctionHP:0003474
  • Third degree atrioventricular blockHP:0001709
  • TremorHP:0001337
  • Urinary incontinenceHP:0000020
  • VentriculomegalyHP:0002119
  • VomitingHP:0002013

Very rare (<4-1%)(14)

  • ArrhythmiaHP:0011675
  • ComaHP:0001259
  • Congestive heart failureHP:0001635
  • DeliriumHP:0031258
  • Erythematous maculeHP:0025475
  • HallucinationsHP:0000738
  • MyelitisHP:0012486
  • MyelopathyHP:0002196
  • MyocarditisHP:0012819
  • PapilledemaHP:0001085
  • PericarditisHP:0001701
  • Premature birthHP:0001622
  • SeizureHP:0001250
  • Spontaneous abortionHP:0005268