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Kikuchi-Fujimoto disease

ORPHA:50918 · Disease · Disorder

HPO 表現型（共 50 項）

Very frequent (99-80%)(1)

  • Cervical lymphadenopathyHP:0025289

Frequent (79-30%)(21)

  • Abnormal lymph node morphologyHP:0002733
  • AlopeciaHP:0001596
  • AnorexiaHP:0002039
  • ChillsHP:0025143
  • Cutaneous photosensitivityHP:0000992
  • Decreased total leukocyte countHP:0001882
  • ErythemaHP:0010783
  • FatigueHP:0012378
  • Increased circulating lactate dehydrogenase concentrationHP:0025435
  • Low-grade feverHP:0011134
  • LymphadenopathyHP:0002716
  • Malar rashHP:0025300
  • Night sweatsHP:0030166
  • Oral ulcerHP:0000155
  • Palpebral edemaHP:0100540
  • PruritusHP:0000989
  • Skin noduleHP:0200036
  • Skin rashHP:0000988
  • VasculitisHP:0002633
  • Vasculitis in the skinHP:0200029
  • Weight lossHP:0001824

Occasional (29-5%)(22)

  • Abnormal blistering of the skinHP:0008066
  • Abnormal pulmonary interstitial morphologyHP:0006530
  • Abnormality of the gastrointestinal tractHP:0011024
  • Abnormality of the neckHP:0000464
  • AnemiaHP:0001903
  • Antinuclear antibody positivityHP:0003493
  • ArthralgiaHP:0002829
  • Decreased total neutrophil countHP:0001875
  • Elevated circulating C-reactive protein concentrationHP:0011227
  • Elevated circulating hepatic transaminase concentrationHP:0002910
  • Elevated erythrocyte sedimentation rateHP:0003565
  • Enlargement of parotid glandHP:0011801
  • Erythematous maculeHP:0025475
  • Increased total lymphocyte countHP:0100827
  • MaculeHP:0012733
  • MeningitisHP:0001287
  • MyalgiaHP:0003326
  • PapuleHP:0200034
  • Skin erosionHP:0200041
  • Skin plaqueHP:0200035
  • SplenomegalyHP:0001744
  • ThrombocytopeniaHP:0001873

Very rare (<4-1%)(6)

  • AtaxiaHP:0001251
  • Generalized lymphadenopathyHP:0008940
  • HepatomegalyHP:0002240
  • MyocarditisHP:0012819
  • Pleural effusionHP:0002202
  • PustuleHP:0200039