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Toxic epidermal necrolysis

ORPHA:537 · Clinical subtype · Subtype of disorder

HPO 表現型（共 39 項）

Very frequent (99-80%)(11)

  • Abnormal blistering of the skinHP:0008066
  • AcantholysisHP:0100792
  • Decreased total neutrophil countHP:0001875
  • DysphagiaHP:0002015
  • ErythemaHP:0010783
  • FatigueHP:0012378
  • MaculeHP:0012733
  • PolydipsiaHP:0001959
  • SepsisHP:0100806
  • ThrombocytopeniaHP:0001873
  • Weight lossHP:0001824

Frequent (79-30%)(8)

  • Abdominal painHP:0002027
  • AnemiaHP:0001903
  • CoughHP:0012735
  • DysuriaHP:0100518
  • Elevated circulating hepatic transaminase concentrationHP:0002910
  • Excessive salivationHP:0003781
  • MalabsorptionHP:0002024
  • Recurrent respiratory infectionsHP:0002205

Occasional (29-5%)(20)

  • Abnormal myocardium morphologyHP:0001637
  • Abnormal pleura morphologyHP:0002103
  • Abnormal vagina morphologyHP:0000142
  • Abnormality of the urethraHP:0000795
  • Acute hepatic failureHP:0006554
  • ConjunctivitisHP:0000509
  • Corneal erosionHP:0200020
  • EntropionHP:0000621
  • Gastrointestinal hemorrhageHP:0002239
  • Intestinal perforationHP:0031368
  • Nausea and vomitingHP:0002017
  • PancreatitisHP:0001733
  • PhotophobiaHP:0000613
  • Renal insufficiencyHP:0000083
  • Respiratory distressHP:0002098
  • Restrictive ventilatory defectHP:0002091
  • Skin ulcerHP:0200042
  • Sudden cardiac deathHP:0001645
  • Tracheoesophageal fistulaHP:0002575
  • Visual lossHP:0000572