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T-cell based immunotherapy-associated cytokine release syndrome

ORPHA:542323 · Particular clinical situation in a disease or syndrome · Disorder

HPO 表現型（共 31 項）

Very frequent (99-80%)(5)

  • Abnormal circulating cytokine concentrationHP:0011112
  • Abnormal circulating interleukin concentrationHP:0011117
  • FatigueHP:0012378
  • FeverHP:0001945
  • Increased inflammatory responseHP:0012649

Frequent (79-30%)(6)

  • HypotensionHP:0002615
  • Increased circulating interferon-gamma concentrationHP:0030356
  • Increased circulating interleukin 6 concentrationHP:0030783
  • MyalgiaHP:0003326
  • Poor appetiteHP:0004396
  • TachycardiaHP:0001649

Occasional (29-5%)(16)

  • ArrhythmiaHP:0011675
  • Capillary leakHP:0030005
  • ConfusionHP:0001289
  • Decreased urine outputHP:0011037
  • DiarrheaHP:0002014
  • Elevated circulating creatinine concentrationHP:0003259
  • Elevated circulating hepatic transaminase concentrationHP:0002910
  • Heart blockHP:0012722
  • HyperbilirubinemiaHP:0002904
  • HypoxemiaHP:0012418
  • NauseaHP:0002018
  • Pleural effusionHP:0002202
  • Pulmonary edemaHP:0100598
  • Reduced left ventricular ejection fractionHP:0012664
  • TachypneaHP:0002789
  • VomitingHP:0002013

Very rare (<4-1%)(4)

  • Acute kidney injuryHP:0001919
  • Disseminated intravascular coagulationHP:0005521
  • Respiratory failureHP:0002878
  • Skin rashHP:0000988