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Leprosy

ORPHA:548 · Disease · Disorder

HPO 表現型（共 47 項）

Very frequent (99-80%)(1)

  • Peripheral neuropathyHP:0009830

Frequent (79-30%)(15)

  • Abnormal autonomic nervous system physiologyHP:0012332
  • Acral ulcerationHP:0006121
  • Acute episodes of neuropathic symptomsHP:0003489
  • Anti-sphingolipid antibody positivityHP:0034102
  • Dissociated sensory lossHP:0010835
  • Enlarged peripheral nerveHP:0012645
  • Entrapment neuropathyHP:0012181
  • HyperkeratosisHP:0000962
  • HypohidrosisHP:0000966
  • Hypopigmented maculeHP:0020073
  • Impaired temperature sensationHP:0010829
  • ParesthesiaHP:0003401
  • Skeletal muscle atrophyHP:0003202
  • Skin noduleHP:0200036
  • Sparse body hairHP:0002231

Occasional (29-5%)(20)

  • Abnormal facial skeleton morphologyHP:0011821
  • Abnormal seventh cranial physiologyHP:0010827
  • Abnormality of the upper respiratory tractHP:0002087
  • Absent eyebrowHP:0002223
  • AlopeciaHP:0001596
  • Autoamputation of digitsHP:0007460
  • Constrictive median neuropathyHP:0012185
  • Corneal ulcerationHP:0012804
  • Decreased corneal sensationHP:0012155
  • DysesthesiaHP:0012534
  • EpistaxisHP:0000421
  • Facial shape deformationHP:0011334
  • Foot dorsiflexor weaknessHP:0009027
  • Loss of eyelashesHP:0011457
  • Muscle weaknessHP:0001324
  • Paralytic lagophthalmosHP:0030003
  • Penetrating foot ulcersHP:0001026
  • Steppage gaitHP:0003376
  • Urticarial plaqueHP:0030351
  • Verrucous papuleHP:0012500

Very rare (<4-1%)(11)

  • Abnormal bone marrow cell morphologyHP:0005561
  • Abnormality of the adrenal glandsHP:0000834
  • Abnormality of the liverHP:0001392
  • Abnormality of the spleenHP:0001743
  • BlindnessHP:0000618
  • Corneal perforationHP:0100583
  • GlaucomaHP:0000501
  • GynecomastiaHP:0000771
  • IritisHP:0001101
  • Testicular massHP:0032404
  • UveitisHP:0000554