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Neuroblastoma

ORPHA:635 · Disease · Disorder

HPO 表現型（共 34 項）

Very frequent (99-80%)(3)

  • Elevated urinary catecholamine levelHP:0011976
  • Neoplasm of the nervous systemHP:0004375
  • NeuroblastomaHP:0003006

Frequent (79-30%)(10)

  • Abdominal distentionHP:0003270
  • Abdominal massHP:0031500
  • AnemiaHP:0001903
  • Chronic diarrheaHP:0002028
  • Elevated circulating catecholamine levelHP:0003334
  • FatigueHP:0012378
  • FeverHP:0001945
  • LymphadenopathyHP:0002716
  • ThrombocytopeniaHP:0001873
  • Weight lossHP:0001824

Occasional (29-5%)(16)

  • Abnormal bleedingHP:0001892
  • Abnormality of coagulationHP:0001928
  • Anemic pallorHP:0001017
  • Antalgic gaitHP:0031955
  • Bone painHP:0002653
  • Elevated urinary homovanillic acidHP:0011977
  • Elevated urinary vanillylmandelic acidHP:0011978
  • Horner syndromeHP:0002277
  • Increased circulating ferritin concentrationHP:0003281
  • Increased circulating lactate dehydrogenase concentrationHP:0025435
  • IrritabilityHP:0000737
  • Pathologic fractureHP:0002756
  • ProptosisHP:0000520
  • Respiratory distressHP:0002098
  • Spinal cord compressionHP:0002176
  • Subcutaneous noduleHP:0001482

Very rare (<4-1%)(5)

  • AtaxiaHP:0001251
  • HypertensionHP:0000822
  • MyoclonusHP:0001336
  • OpsoclonusHP:0010543
  • Periorbital ecchymosis with tarsal plate sparingHP:0025553