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IgG4-related thyroid disease

ORPHA:64744 · Clinical subtype · Subtype of disorder

HPO 表現型（共 25 項）

Very frequent (99-80%)(2)

  • GoiterHP:0000853
  • ThyroiditisHP:0100646

Frequent (79-30%)(5)

  • Anti-thyroglobulin antibody positivityHP:0032069
  • Anti-thyroid peroxidase antibody positivityHP:0025379
  • Hashimoto thyroiditisHP:0000872
  • HypothyroidismHP:0000821
  • Increased circulating IgG4 concentrationHP:0032300

Occasional (29-5%)(8)

  • AutoimmunityHP:0002960
  • DysphagiaHP:0002015
  • Euthyroid goiterHP:0009798
  • Graves diseaseHP:0100647
  • HypocalcemiaHP:0002901
  • Nodular goiterHP:0005994
  • Tracheal stenosisHP:0002777
  • Vocal cord paralysisHP:0001605

Very rare (<4-1%)(8)

  • Abnormal mediastinum morphologyHP:0045026
  • Abnormal pituitary gland morphologyHP:0012503
  • Abnormality of the ocular adnexaHP:0032039
  • Pancreatic fibrosisHP:0100732
  • Retroperitoneal fibrosisHP:0005200
  • Sclerosing cholangitisHP:0030991
  • SialadenitisHP:0031281
  • Thyrotoxicosis with diffuse goiterHP:0011784

Excluded (0%)(2)

  • AllergyHP:0012393
  • NeoplasmHP:0002664