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Progressive supranuclear palsy

ORPHA:683 · Disease · Disorder

HPO 表現型（共 32 項）

Very frequent (99-80%)(9)

  • Abnormal synaptic transmissionHP:0012535
  • DysphagiaHP:0002015
  • FallsHP:0002527
  • ImpulsivityHP:0100710
  • Neuronal loss in central nervous systemHP:0002529
  • Postural instabilityHP:0002172
  • Supranuclear gaze palsyHP:0000605
  • Supranuclear ophthalmoplegiaHP:0000623
  • Unsteady gaitHP:0002317

Frequent (79-30%)(19)

  • ApathyHP:0000741
  • AphasiaHP:0002381
  • BlepharospasmHP:0000643
  • BradykinesiaHP:0002067
  • Cerebral cortical atrophyHP:0002120
  • Cognitive impairmentHP:0100543
  • Delayed speech and language developmentHP:0000750
  • DepressionHP:0000716
  • DysarthriaHP:0001260
  • DystoniaHP:0001332
  • Emotional labilityHP:0000712
  • GliosisHP:0002171
  • IrritabilityHP:0000737
  • Memory impairmentHP:0002354
  • Pseudobulbar signsHP:0002200
  • Slow saccadic eye movementsHP:0000514
  • Vertical supranuclear gaze palsyHP:0000511
  • VertigoHP:0002321
  • Visual impairmentHP:0000505

Occasional (29-5%)(4)

  • Abnormality of eye movementHP:0000496
  • DementiaHP:0000726
  • RigidityHP:0002063
  • TremorHP:0001337