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Intrahepatic cholestasis of pregnancy

ORPHA:69665 · Disease · Disorder

HPO 表現型（共 27 項）

Very frequent (99-80%)(2)

  • Increased serum bile acid concentrationHP:0012202
  • PruritusHP:0000989

Frequent (79-30%)(3)

  • Abnormality of the digestive systemHP:0025031
  • Elevated circulating hepatic transaminase concentrationHP:0002910
  • InsomniaHP:0100785

Occasional (29-5%)(10)

  • Abnormal circulating interleukin concentrationHP:0011117
  • Abnormal pineal melatonin secretionHP:0012689
  • DepressionHP:0000716
  • Elevated circulating alkaline phosphatase concentrationHP:0003155
  • HyperbilirubinemiaHP:0002904
  • Meconium stained amniotic fluidHP:0012420
  • Neonatal respiratory distressHP:0002643
  • Palmar pruritusHP:0031248
  • PreeclampsiaHP:0100602
  • Pruritus on footHP:0030900

Very rare (<4-1%)(10)

  • Abdominal painHP:0002027
  • Abnormality of the pancreasHP:0001732
  • AscitesHP:0001541
  • AsterixisHP:0012164
  • CholecystitisHP:0001082
  • HypothyroidismHP:0000821
  • JaundiceHP:0000952
  • Premature birthHP:0001622
  • Small for gestational ageHP:0001518
  • TremorHP:0001337

Excluded (0%)(2)

  • AutoimmunityHP:0002960
  • Skin rashHP:0000988