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Chronic thromboembolic pulmonary hypertension

ORPHA:70591 · Disease · Disorder

HPO 表現型（共 37 項）

Very frequent (99-80%)(3)

  • Congestive heart failureHP:0001635
  • Increased pulmonary vascular resistanceHP:0005317
  • Pulmonary arterial hypertensionHP:0002092

Frequent (79-30%)(7)

  • Deep venous thrombosisHP:0002625
  • Exertional dyspneaHP:0002875
  • FatigueHP:0012378
  • PalpitationsHP:0001962
  • Pulmonary embolismHP:0002204
  • Reduced FEV1/FVC ratioHP:0030877
  • Reduced vital capacityHP:0002792

Occasional (29-5%)(23)

  • Abnormal left ventricular functionHP:0005162
  • Abnormal T-waveHP:0005135
  • Abnormality of blood and blood-forming tissuesHP:0001871
  • Abnormality of von Willebrand factorHP:0012146
  • Antiphospholipid antibody positivityHP:0003613
  • AutoimmunityHP:0002960
  • Cardiac shuntHP:0001693
  • Central sleep apneaHP:0010536
  • Complete right bundle branch blockHP:0011712
  • DepressionHP:0000716
  • DysfibrinogenemiaHP:0011901
  • EdemaHP:0000969
  • Elevated circulating C-reactive protein concentrationHP:0011227
  • Elevated circulating HDL-C concentrationHP:0012184
  • HypocapniaHP:0012417
  • Increased factor VIII activityHP:0030977
  • Lupus anticoagulantHP:0025343
  • ObesityHP:0001513
  • Recurrent thromboembolismHP:0004831
  • Right atrial enlargementHP:0030718
  • Right ventricular dilatationHP:0005133
  • Right ventricular failureHP:0001708
  • SyncopeHP:0001279

Very rare (<4-1%)(4)

  • Inflammation of the large intestineHP:0002037
  • Myeloproliferative disorderHP:0005547
  • NeoplasmHP:0002664
  • OsteomyelitisHP:0002754