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Dowling-Degos disease

ORPHA:79145 · Disease · Disorder

HPO 表現型（共 25 項）

Very frequent (99-80%)(1)

  • Progressive reticulate hyperpigmentationHP:0007456

Frequent (79-30%)(3)

  • Abnormality of the neckHP:0000464
  • HyperkeratosisHP:0000962
  • Inguinal frecklingHP:0030052

Occasional (29-5%)(12)

  • Abnormal fingernail morphologyHP:0001231
  • Abnormality of the handHP:0001155
  • Acne inversaHP:0040154
  • Digital pitting scarHP:0031293
  • Erythematous papuleHP:0030350
  • Heat intoleranceHP:0002046
  • Hyperkeratotic papuleHP:0045059
  • Hypermelanotic maculeHP:0001034
  • Hyperpigmented papuleHP:0025473
  • Penile frecklingHP:0031447
  • PruritusHP:0000989
  • Scrotal hyperpigmentationHP:0012855

Very rare (<4-1%)(9)

  • Anal margin squamous cell carcinomaHP:0030442
  • ArthritisHP:0001369
  • Epidermoid cystHP:0200040
  • Generalized abnormality of skinHP:0011354
  • Hypopigmented maculeHP:0020073
  • KeratoacanthomaHP:0031525
  • Mixed hypo- and hyperpigmentation of the skinHP:0009123
  • Palmar pitsHP:0010610
  • Skin vesicleHP:0200037