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Antisynthetase syndrome

ORPHA:81 · Disease · Disorder

HPO 表現型（共 44 項）

Very frequent (99-80%)(9)

  • Abnormal pulmonary interstitial morphologyHP:0006530
  • AutoimmunityHP:0002960
  • Chest painHP:0100749
  • CoughHP:0012735
  • Muscle weaknessHP:0001324
  • MyalgiaHP:0003326
  • MyositisHP:0100614
  • Pulmonary fibrosisHP:0002206
  • Respiratory insufficiencyHP:0002093

Frequent (79-30%)(22)

  • Anti-alanyl-tRNA synthetase antibody positivityHP:0034145
  • Anti-aminoacyl-tRNA synthetase antibody positivityHP:0034147
  • Anti-asparaginyl-tRNA synthetase antibody positivityHP:0034151
  • Anti-cytosolic-5-nucleotidase-1A antibody positivityHP:0034153
  • Anti-glycyl tRNA-synthetase antibody positivityHP:0034146
  • Anti-histidyl tRNA synthetase antibody positivityHP:0034152
  • Anti-isoleucyl tRNA-synthetase antibody positivityHP:0034148
  • Anti-phenylalanyl tRNA synthetase antibody positivityHP:0034149
  • Anti-threonyl-tRNA synthetase antibody positivityHP:0034143
  • Anti-tyrosyl-tRNA synthetase antibody positivityHP:0034150
  • ArthralgiaHP:0002829
  • ArthritisHP:0001369
  • DyspneaHP:0002094
  • EdemaHP:0000969
  • Elevated circulating creatine kinase activityHP:0003236
  • EMG abnormalityHP:0003457
  • FeverHP:0001945
  • HypotoniaHP:0001252
  • Keratoconjunctivitis siccaHP:0001097
  • Lack of skin elasticityHP:0100679
  • Raynaud phenomenonHP:0030880
  • XerostomiaHP:0000217

Occasional (29-5%)(13)

  • Abnormality of the voiceHP:0001608
  • Aortic regurgitationHP:0001659
  • DysphagiaHP:0002015
  • Hiker's feetHP:6001014
  • Joint dislocationHP:0001373
  • Mechanic's handsHP:6001013
  • MyocarditisHP:0012819
  • NeoplasmHP:0002664
  • PruritusHP:0000989
  • Pulmonary arterial hypertensionHP:0002092
  • Recurrent respiratory infectionsHP:0002205
  • Skin rashHP:0000988
  • Telangiectasia of the skinHP:0100585