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Primary myelofibrosis

ORPHA:824 · Disease · Disorder

HPO 表現型（共 36 項）

Very frequent (99-80%)(1)

  • Abnormal bone marrow cell morphologyHP:0005561

Frequent (79-30%)(10)

  • Abnormal megakaryocyte morphologyHP:0012143
  • Abnormality of blood and blood-forming tissuesHP:0001871
  • AnemiaHP:0001903
  • Constitutional symptomHP:0025142
  • FatigueHP:0012378
  • HepatomegalyHP:0002240
  • HepatosplenomegalyHP:0001433
  • PallorHP:0000980
  • SplenomegalyHP:0001744
  • ThrombocytopeniaHP:0001873

Occasional (29-5%)(20)

  • Abnormal bleedingHP:0001892
  • Abnormal thrombosisHP:0001977
  • AnorexiaHP:0002039
  • Arterial thrombosisHP:0004420
  • Bone marrow hypercellularityHP:0031020
  • Easy fatigabilityHP:0003388
  • EcchymosisHP:0031364
  • Extramedullary hematopoiesisHP:0001978
  • FeverHP:0001945
  • Flank painHP:0030157
  • Increased total leukocyte countHP:0001974
  • Low-grade feverHP:0011134
  • LymphadenopathyHP:0002716
  • PancytopeniaHP:0001876
  • PetechiaeHP:0000967
  • PoikilocytosisHP:0004447
  • Portal hypertensionHP:0001409
  • PurpuraHP:0000979
  • ThrombocytosisHP:0001894
  • Venous thrombosisHP:0004936

Very rare (<4-1%)(4)

  • CachexiaHP:0004326
  • HemangiomaHP:0001028
  • Hematological neoplasmHP:0004377
  • Increased circulating lactate dehydrogenase concentrationHP:0025435

Excluded (0%)(1)

  • Autoimmune antibody positivityHP:0030057