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Adult-onset Still disease

ORPHA:829 · Disease · Disorder

HPO 表現型（共 59 項）

Very frequent (99-80%)(14)

  • ArthralgiaHP:0002829
  • Arthralgia/arthritisHP:0005059
  • ArthritisHP:0001369
  • Elevated circulating C-reactive protein concentrationHP:0011227
  • Elevated erythrocyte sedimentation rateHP:0003565
  • ErythemaHP:0010783
  • FatigueHP:0012378
  • FeverHP:0001945
  • Increased circulating ferritin concentrationHP:0003281
  • Increased total leukocyte countHP:0001974
  • Increased total neutrophil countHP:0011897
  • Joint swellingHP:0001386
  • PruritusHP:0000989
  • Skin rashHP:0000988

Frequent (79-30%)(18)

  • Abdominal painHP:0002027
  • AnemiaHP:0001903
  • AstheniaHP:0025406
  • Elevated circulating alkaline phosphatase concentrationHP:0003155
  • Elevated circulating hepatic transaminase concentrationHP:0002910
  • Generalized lymphadenopathyHP:0008940
  • HepatomegalyHP:0002240
  • Koebner PhenomenonHP:6000933
  • LymphadenopathyHP:0002716
  • Maculopapular exanthemaHP:0040186
  • MyalgiaHP:0003326
  • PharyngalgiaHP:0033050
  • PharyngitisHP:0025439
  • Pleural effusionHP:0002202
  • PleuritisHP:0002102
  • SplenomegalyHP:0001744
  • Transient pulmonary infiltratesHP:0005828
  • Weight lossHP:0001824

Occasional (29-5%)(18)

  • Abnormal circulating lipid concentrationHP:0003119
  • AnorexiaHP:0002039
  • Antinuclear antibody positivityHP:0003493
  • Bone marrow hypocellularityHP:0005528
  • Cartilage destructionHP:0100773
  • Elevated circulating aldolase concentrationHP:0012544
  • EncephalopathyHP:0001298
  • HemophagocytosisHP:0012156
  • HepatitisHP:0012115
  • Interstitial pneumonitisHP:0006515
  • LymphadenitisHP:0002840
  • MyocarditisHP:0012819
  • NauseaHP:0002018
  • PancreatitisHP:0001733
  • PericarditisHP:0001701
  • ProteinuriaHP:0000093
  • Respiratory distressHP:0002098
  • Rheumatoid factor positiveHP:0002923

Very rare (<4-1%)(6)

  • Amyloid depositionHP:0011034
  • ConjunctivitisHP:0000509
  • Disseminated intravascular coagulationHP:0005521
  • EpiscleritisHP:0100534
  • Non-infectious meningitisHP:0033430
  • UveitisHP:0000554

Excluded (0%)(3)

  • LymphomaHP:0002665
  • SepsisHP:0100806
  • Severe Epstein Barr virus infectionHP:0031693