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Acute disseminated encephalomyelitis

ORPHA:83597 · Disease · Disorder

HPO 表現型（共 53 項）

Obligate (100%)(1)

  • EncephalopathyHP:0001298

Very frequent (99-80%)(3)

  • CNS demyelinationHP:0007305
  • Diffuse white matter abnormalitiesHP:0007204
  • EEG with generalized slow activityHP:0010845

Frequent (79-30%)(23)

  • Abnormal basal ganglia morphologyHP:0002134
  • Abnormal brainstem MRI signal intensityHP:0012747
  • Abnormal cerebellum morphologyHP:0001317
  • Abnormal periventricular white matter morphologyHP:0002518
  • Abnormal pyramidal signHP:0007256
  • Abnormal spinal cord morphologyHP:0002143
  • Abnormal thalamic MRI signal intensityHP:0012696
  • Anti-myelin oligodendrocyte glycoprotein antibody positivityHP:0032492
  • AtaxiaHP:0001251
  • Atypical behaviorHP:0000708
  • Cerebral edemaHP:0002181
  • CSF lymphocytic pleiocytosisHP:0200149
  • Disseminated viral infectionHP:0031696
  • FeverHP:0001945
  • HeadacheHP:0002315
  • HypersomniaHP:0100786
  • Increased CSF protein concentrationHP:0002922
  • Interictal EEG abnormalityHP:0025373
  • IrritabilityHP:0000737
  • Mental deteriorationHP:0001268
  • MyelitisHP:0012486
  • NauseaHP:0002018
  • SeizureHP:0001250

Occasional (29-5%)(17)

  • Abnormal speech patternHP:0002167
  • Aggressive behaviorHP:0000718
  • Atypical absence status epilepticusHP:0011151
  • ComaHP:0001259
  • ConfusionHP:0001289
  • Cranial nerve paralysisHP:0006824
  • EEG with focal slow activityHP:0010843
  • EEG with focal spikesHP:0011193
  • Eye movement-induced painHP:0030857
  • HemiparesisHP:0001269
  • Muscle weaknessHP:0001324
  • Nuchal rigidityHP:0031179
  • Optic neuritisHP:0100653
  • Respiratory failure requiring assisted ventilationHP:0004887
  • Somatic sensory dysfunctionHP:0003474
  • Visual lossHP:0000572
  • VomitingHP:0002013

Very rare (<4-1%)(9)

  • Diaphragmatic paralysisHP:0006597
  • HSV encephalitisHP:0012302
  • Hypointensity of cerebral white matter on MRIHP:0007103
  • Involuntary movementsHP:0004305
  • Post-vaccination measlesHP:0020088
  • Post-vaccination rubellaHP:0020089
  • Severe Epstein Barr virus infectionHP:0031693
  • Severe parainfluenza infectionHP:0031695
  • Viral hepatitisHP:0006562