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AL amyloidosis
ORPHA:85443 · Disease · Disorder
HPO 表現型（共 65 項）
Very frequent (99-80%)(2)
- Congestive heart failureHP:0001635
- FatigueHP:0012378
Frequent (79-30%)(24)
- Abnormal atrioventricular conductionHP:0005150
- Abnormal EKGHP:0003115
- Abnormal pulmonary interstitial morphologyHP:0006530
- Abnormality of taste sensationHP:0000223
- AlbuminuriaHP:0012592
- Bundle branch blockHP:0011710
- Decreased QRS voltageHP:0025077
- Elevated circulating NT-proBNP concentrationHP:0031185
- Erectile dysfunctionHP:0100639
- Hepatic amyloidosisHP:0012280
- Hypertrophic cardiomyopathyHP:0001639
- Increased circulating immunoglobulin concentrationHP:0010702
- Increased circulating troponin I concentrationHP:0410173
- Increased circulating troponin T concentrationHP:0410174
- Left ventricular hypertrophyHP:0001712
- MalabsorptionHP:0002024
- Monoclonal light chain cardiac amyloidosisHP:0031326
- Nephrotic range proteinuriaHP:0012593
- Nephrotic syndromeHP:0000100
- Periorbital purpuraHP:0025552
- ProteinuriaHP:0000093
- Renal interstitial amyloid depositsHP:0032613
- Sensorimotor neuropathyHP:0007141
- Weight lossHP:0001824
Occasional (29-5%)(33)
- Abdominal distentionHP:0003270
- Abnormal autonomic nervous system physiologyHP:0012332
- Abnormal cardiac atrium morphologyHP:0005120
- Abnormal cardiac ventricle morphologyHP:0001713
- Abnormal P waveHP:0031595
- Abnormal salivary gland morphologyHP:0010286
- AnemiaHP:0001903
- Aortic valve stenosisHP:0001650
- ArrhythmiaHP:0011675
- Biceps tendon ruptureHP:6001262
- Bruising susceptibilityHP:0000978
- ConstipationHP:0002019
- Constrictive median neuropathyHP:0012185
- DiarrheaHP:0002014
- DyspneaHP:0002094
- Elevated circulating alkaline phosphatase concentrationHP:0003155
- HepatomegalyHP:0002240
- Howell-Jolly bodiesHP:0032550
- HypoalbuminemiaHP:0003073
- Jaw claudicationHP:0030164
- Left ventricular diastolic dysfunctionHP:0025168
- Nonproductive coughHP:0031246
- Obstructive sleep apneaHP:0002870
- Peripheral edemaHP:0012398
- Peripheral neuropathyHP:0009830
- Postural hypotension with compensatory tachycardiaHP:0005307
- Pulmonary interstitial high-resolution computed tomography abnormalityHP:0025389
- Reduced factor X activityHP:0008321
- Renal insufficiencyHP:0000083
- Spinal canal stenosisHP:0003416
- Sudden cardiac deathHP:0001645
- SyncopeHP:0001279
- XerostomiaHP:0000217
Very rare (<4-1%)(5)
- DysphagiaHP:0002015
- Gastrointestinal hemorrhageHP:0002239
- GastroparesisHP:0002578
- Hoarse voiceHP:0001609
- MacroglossiaHP:0000158
Excluded (0%)(1)
- Reduced left ventricular ejection fractionHP:0012664