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Granulomatosis with polyangiitis

ORPHA:900 · Disease · Disorder

HPO 表現型（共 80 項）

Very frequent (99-80%)(17)

  • Abnormal oral cavity morphologyHP:0000163
  • Abnormality of the noseHP:0000366
  • ArthralgiaHP:0002829
  • AutoimmunityHP:0002960
  • Cerebral ischemiaHP:0002637
  • EpistaxisHP:0000421
  • FatigueHP:0012378
  • FeverHP:0001945
  • GlomerulopathyHP:0100820
  • GranulomatosisHP:0002955
  • HematuriaHP:0000790
  • Otitis mediaHP:0000388
  • Pulmonary infiltratesHP:0002113
  • Recurrent respiratory infectionsHP:0002205
  • SinusitisHP:0000246
  • VasculitisHP:0002633
  • Weight lossHP:0001824

Frequent (79-30%)(28)

  • Abdominal painHP:0002027
  • Abnormality of the hypothalamus-pituitary axisHP:0000864
  • Anti-myeloperoxidase antibody positivityHP:0033559
  • Anti-neutrophil elastase antibody positivityHP:0034104
  • Anti-proteinase 3 antibody positivityHP:0033557
  • ArthritisHP:0001369
  • Chest painHP:0100749
  • Chronic pulmonary obstructionHP:0006510
  • CoughHP:0012735
  • Cytoplasmic antineutrophil antibody positivityHP:0032230
  • Elevated circulating C-reactive protein concentrationHP:0011227
  • Elevated erythrocyte sedimentation rateHP:0003565
  • GlomerulonephritisHP:0000099
  • HemoptysisHP:0002105
  • Increased inflammatory responseHP:0012649
  • Inflammatory abnormality of the eyeHP:0100533
  • Nasolacrimal duct obstructionHP:0000579
  • Nausea and vomitingHP:0002017
  • PapuleHP:0200034
  • Periorbital edemaHP:0100539
  • Peripheral neuropathyHP:0009830
  • Polyarticular arthritisHP:0005764
  • ProteinuriaHP:0000093
  • Pulmonary fibrosisHP:0002206
  • Recurrent intrapulmonary hemorrhageHP:0006535
  • Respiratory insufficiencyHP:0002093
  • ScleritisHP:0100532
  • Skin rashHP:0000988

Occasional (29-5%)(35)

  • Angina pectorisHP:0001681
  • ArrhythmiaHP:0011675
  • Chronic otitis mediaHP:0000389
  • Cranial nerve paralysisHP:0006824
  • Diabetes insipidusHP:0000873
  • Diffuse alveolar hemorrhageHP:0025420
  • GangreneHP:0100758
  • Gastrointestinal hemorrhageHP:0002239
  • HeadacheHP:0002315
  • HemiplegiaHP:0002301
  • HydronephrosisHP:0000126
  • HypertensionHP:0000822
  • Intestinal obstructionHP:0005214
  • KeratitisHP:0000491
  • MeningitisHP:0001287
  • MyalgiaHP:0003326
  • PancreatitisHP:0001733
  • PericarditisHP:0001701
  • Pleural effusionHP:0002202
  • PleuritisHP:0002102
  • ProptosisHP:0000520
  • ProstatitisHP:0000024
  • Pulmonary noduleHP:0033608
  • PurpuraHP:0000979
  • Renal insufficiencyHP:0000083
  • Restrictive ventilatory defectHP:0002091
  • RetinopathyHP:0000488
  • SeizureHP:0001250
  • Sensorineural hearing impairmentHP:0000407
  • Sensory neuropathyHP:0000763
  • Skin ulcerHP:0200042
  • Subglottic stenosisHP:0001607
  • Ureteral stenosisHP:0000071
  • Venous thrombosisHP:0004936
  • Visual impairmentHP:0000505