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Localized scleroderma
ORPHA:90289 · Disease · Disorder
HPO 表現型（共 55 項）
Very frequent (99-80%)(1)
- Thickened skinHP:0001072
Frequent (79-30%)(4)
- ArthralgiaHP:0002829
- Cutaneous sclerotic plaqueHP:0031359
- Localized skin lesionHP:0011355
- Stiff skinHP:0030053
Occasional (29-5%)(28)
- Abnormal cheek morphologyHP:0004426
- Abnormal facial skeleton morphologyHP:0011821
- Abnormal upper lip morphologyHP:0000177
- Abnormality of the dentitionHP:0000164
- Abnormality of the musculoskeletal systemHP:0033127
- Abnormality of visionHP:0000504
- ArthritisHP:0001369
- AutoimmunityHP:0002960
- Dental malocclusionHP:0000689
- ErythemaHP:0010783
- Erythematous plaqueHP:0025474
- Facial asymmetryHP:0000324
- FasciitisHP:0100537
- Flexion contractureHP:0001371
- Gastroesophageal refluxHP:0002020
- HeadacheHP:0002315
- Hemifacial atrophyHP:0011331
- Hyperpigmentation of the skinHP:0000953
- Hypopigmented skin patchesHP:0001053
- Infra-orbital creaseHP:0100876
- MigraineHP:0002076
- MyopathyHP:0003198
- Patchy alopeciaHP:0002232
- Progressive loss of facial adipose tissueHP:0009019
- Sclerosis of finger phalanxHP:0100899
- Short dental rootHP:0006336
- Upper limb asymmetryHP:0100560
- UveitisHP:0000554
Very rare (<4-1%)(22)
- Abnormal blistering of the skinHP:0008066
- Abnormal bone structureHP:0003330
- Abnormal skin adnexa morphologyHP:0011138
- Abnormality of the cardiovascular systemHP:0001626
- Abnormality of the kidneyHP:0000077
- Abnormality of the nervous systemHP:0000707
- Abnormality of the noseHP:0000366
- Abnormality of the respiratory systemHP:0002086
- Abnormality on pulmonary function testingHP:0030878
- ArrhythmiaHP:0011675
- Deeply set eyeHP:0000490
- EsophagitisHP:0100633
- Focal impaired awareness seizureHP:0002384
- Hashimoto thyroiditisHP:0000872
- ProptosisHP:0000520
- Raynaud phenomenonHP:0030880
- SeizureHP:0001250
- Skeletal muscle atrophyHP:0003202
- Skin erosionHP:0200041
- StrokeHP:0001297
- VasculitisHP:0002633
- VitiligoHP:0001045