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Non-acquired panhypopituitarism

ORPHA:90695 · Disease · Disorder

HPO 表現型（共 27 項）

Obligate (100%)(1)

  • HypopituitarismHP:0040075

Frequent (79-30%)(17)

  • Abnormal prolactin levelHP:0040086
  • Abnormality of secondary sexual hairHP:0009888
  • AmenorrheaHP:0000141
  • Anterior pituitary hypoplasiaHP:0010627
  • Aplasia/Hypoplasia of the breastsHP:0010311
  • Decreased circulating ACTH concentrationHP:0002920
  • Decreased response to growth hormone stimulation testHP:0000824
  • Decreased testicular sizeHP:0008734
  • Depressed nasal ridgeHP:0000457
  • FatigueHP:0012378
  • Growth delayHP:0001510
  • HypoglycemiaHP:0001943
  • Hypogonadotropic hypogonadismHP:0000044
  • HypotensionHP:0002615
  • InfertilityHP:0000789
  • Pituitary hypothyroidismHP:0008245
  • Short statureHP:0004322

Occasional (29-5%)(7)

  • Absence of secondary sex characteristicsHP:0008187
  • ConstipationHP:0002019
  • Delayed pubertyHP:0000823
  • Delayed skeletal maturationHP:0002750
  • OsteopeniaHP:0000938
  • Osteoporosis of vertebraeHP:0005625
  • Pituitary dwarfismHP:0000839

Very rare (<4-1%)(2)

  • Ectopic anterior pituitary glandHP:0012731
  • Ectopic posterior pituitaryHP:0011755