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Simple cryoglobulinemia

ORPHA:91139 · Disease · Disorder

HPO 表現型（共 55 項）

Very frequent (99-80%)(3)

  • Abnormality of blood and blood-forming tissuesHP:0001871
  • Cold urticariaHP:0410135
  • PurpuraHP:0000979

Frequent (79-30%)(12)

  • Acral ulcerationHP:0006121
  • Distal peripheral sensory neuropathyHP:0007067
  • FatigueHP:0012378
  • Increased circulating IgM concentrationHP:0003496
  • Livedo racemosaHP:0033260
  • Localized skin lesionHP:0011355
  • Multiple mononeuropathyHP:0032018
  • ParaproteinemiaHP:0031047
  • Peripheral neuropathyHP:0009830
  • Raynaud phenomenonHP:0030880
  • Sensorimotor neuropathyHP:0007141
  • Unexplained feversHP:0001955

Occasional (29-5%)(18)

  • Abnormality of the kidneyHP:0000077
  • ArthralgiaHP:0002829
  • ArthritisHP:0001369
  • B-cell lymphomaHP:0012191
  • HypertensionHP:0000822
  • Membranoproliferative glomerulonephritisHP:0000793
  • Mesangial hypercellularityHP:0012574
  • Microscopic hematuriaHP:0002907
  • Monoclonal elevation of circulating IgG concentrationHP:0032290
  • Monoclonal elevation of circulating IgM concentrationHP:0005508
  • Multiple myelomaHP:0006775
  • ParesthesiaHP:0003401
  • ProteinuriaHP:0000093
  • Renal insufficiencyHP:0000083
  • Spontaneous pain sensationHP:0010833
  • Vascular skin abnormalityHP:0011276
  • VasculitisHP:0002633
  • Weight lossHP:0001824

Very rare (<4-1%)(22)

  • Abdominal painHP:0002027
  • Abnormal heart morphologyHP:0001627
  • Abnormal lung morphologyHP:0002088
  • Abnormality of the gastrointestinal tractHP:0011024
  • Chronic lymphatic leukemiaHP:0005550
  • Congestive heart failureHP:0001635
  • Cranial nerve paralysisHP:0006824
  • Functional motor deficitHP:0004302
  • Gastrointestinal hemorrhageHP:0002239
  • HeadacheHP:0002315
  • Monoclonal elevation of circulating IgAHP:0032335
  • Morphological central nervous system abnormalityHP:0002011
  • Myocardial infarctionHP:0001658
  • NephritisHP:0000123
  • Nephrotic syndromeHP:0000100
  • PericarditisHP:0001701
  • Progressive neurologic deteriorationHP:0002344
  • Reduced circulating complement concentrationHP:0004431
  • Rheumatoid factor positiveHP:0002923
  • SeizureHP:0001250
  • StrokeHP:0001297
  • Viral hepatitisHP:0006562