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TSH-secreting pituitary adenoma

ORPHA:91347 · Disease · Disorder

HPO 表現型（共 66 項）

Very frequent (99-80%)(5)

  • Abnormal pituitary gland morphologyHP:0012503
  • Elevated circulating thyroid-stimulating hormone concentrationHP:0002925
  • Enlarged pituitary glandHP:0012505
  • GoiterHP:0000853
  • HyperthyroidismHP:0000836

Frequent (79-30%)(33)

  • Abnormal hair quantityHP:0011362
  • Abnormality of the menstrual cycleHP:0000140
  • Adrenocorticotropic hormone deficiencyHP:0011748
  • Adrenocorticotropin deficient adrenal insufficiencyHP:0011735
  • Central adrenal insufficiencyHP:0011734
  • Decreased circulating ACTH concentrationHP:0002920
  • Decreased female libidoHP:0030018
  • Decreased fertility in femalesHP:0000868
  • Decreased fertility in malesHP:0012041
  • Easy fatigabilityHP:0003388
  • Erectile dysfunctionHP:0100639
  • FatigueHP:0012378
  • Female hypogonadismHP:0000134
  • GynecomastiaHP:0000771
  • HeadacheHP:0002315
  • HyperhidrosisHP:0000975
  • HypogonadismHP:0000135
  • Hypogonadotropic hypogonadismHP:0000044
  • HypotensionHP:0002615
  • ImpotenceHP:0000802
  • Irregular menstruationHP:0000858
  • Male hypogonadismHP:0000026
  • Nausea and vomitingHP:0002017
  • OsteopeniaHP:0000938
  • OsteoporosisHP:0000939
  • PallorHP:0000980
  • PalpitationsHP:0001962
  • Progressive visual lossHP:0000529
  • Secondary growth hormone deficiencyHP:0008240
  • Thyroid crisisHP:0011782
  • TremorHP:0001337
  • VomitingHP:0002013
  • Weight lossHP:0001824

Occasional (29-5%)(28)

  • Abducens palsyHP:0006897
  • Abnormal visual field testHP:0030588
  • Bitemporal hemianopiaHP:0030521
  • BlindnessHP:0000618
  • Congestive heart failureHP:0001635
  • Cranial nerve paralysisHP:0006824
  • Delayed pubertyHP:0000823
  • DiplopiaHP:0000651
  • Elevated circulating growth hormone concentrationHP:0000845
  • Euthyroid hyperthyroxinemiaHP:0008247
  • Fourth cranial nerve palsyHP:0007011
  • HemianopiaHP:0012377
  • Heteronymous hemianopiaHP:0030517
  • HypertensionHP:0000822
  • HypokalemiaHP:0002900
  • Increased circulating gonadotropin levelHP:0000837
  • Increased circulating prolactin concentrationHP:0000870
  • InfertilityHP:0000789
  • Internal ophthalmoplegiaHP:0007942
  • Oculomotor nerve palsyHP:0012246
  • Pericardial effusionHP:0001698
  • Periodic hypokalemic paresisHP:0008153
  • PtosisHP:0000508
  • SeizureHP:0001250
  • Sudden loss of visual acuityHP:0001117
  • Supraventricular arrhythmiaHP:0005115
  • Ventricular arrhythmiaHP:0004308
  • VertigoHP:0002321