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Sheehan syndrome

ORPHA:91355 · Malformation syndrome · Disorder

HPO 表現型（共 49 項）

Very frequent (99-80%)(7)

  • Adrenocorticotropic hormone deficiencyHP:0011748
  • Adrenocorticotropin deficient adrenal insufficiencyHP:0011735
  • Chronic fatigueHP:0012432
  • Decreased circulating cortisol levelHP:0008163
  • OligomenorrheaHP:0000876
  • PanhypopituitarismHP:0000871
  • Secondary growth hormone deficiencyHP:0008240

Frequent (79-30%)(23)

  • Abnormal size of pituitary glandHP:0012504
  • AmenorrheaHP:0000141
  • Blurred visionHP:0000622
  • Breast hypoplasiaHP:0003187
  • Central adrenal insufficiencyHP:0011734
  • Decreased female libidoHP:0030018
  • Decreased serum estradiolHP:0008214
  • Dry skinHP:0000958
  • DyspareuniaHP:0030016
  • Gonadotropin deficiencyHP:0008213
  • HeadacheHP:0002315
  • HypoglycemiaHP:0001943
  • HyposthenuriaHP:0003158
  • ImpotenceHP:0000802
  • NauseaHP:0002018
  • Normochromic anemiaHP:0001895
  • Orthostatic hypotensionHP:0001278
  • PallorHP:0000980
  • Pituitary hypothyroidismHP:0008245
  • Progressive visual field defectsHP:0007987
  • Reduced circulating prolactin concentrationHP:0008202
  • Sparse axillary hairHP:0002215
  • Sparse pubic hairHP:0002225

Occasional (29-5%)(16)

  • Antinuclear antibody positivityHP:0003493
  • ArthralgiaHP:0002829
  • BradycardiaHP:0001662
  • ChillsHP:0025143
  • Chronic lymphocytic meningitisHP:0007041
  • ConstipationHP:0002019
  • DiplopiaHP:0000651
  • Hashimoto thyroiditisHP:0000872
  • HyponatremiaHP:0002902
  • Muscle weaknessHP:0001324
  • ObesityHP:0001513
  • PalpitationsHP:0001962
  • Poor appetiteHP:0004396
  • Sensorineural hearing impairmentHP:0000407
  • Thunderclap headacheHP:0030907
  • VertigoHP:0002321

Very rare (<4-1%)(3)

  • Central diabetes insipidusHP:0000863
  • ComaHP:0001259
  • PsychosisHP:0000709