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Pediatric systemic lupus erythematosus

ORPHA:93552 · Disease · Disorder

HPO 表現型（共 53 項）

Very frequent (99-80%)(3)

  • Decreased circulating complement C3 concentrationHP:0005421
  • Decreased circulating complement C4 concentrationHP:0045042
  • Elevated erythrocyte sedimentation rateHP:0003565

Frequent (79-30%)(21)

  • Abnormality of the gastrointestinal tractHP:0011024
  • Abnormality of the skinHP:0000951
  • Abnormality of the urinary systemHP:0000079
  • Antinuclear antibody positivityHP:0003493
  • Antiphospholipid antibody positivityHP:0003613
  • Decreased total leukocyte countHP:0001882
  • Decreased total lymphocyte countHP:0001888
  • EdemaHP:0000969
  • FeverHP:0001945
  • HematuriaHP:0000790
  • Increased circulating lactate dehydrogenase concentrationHP:0025435
  • LymphadenopathyHP:0002716
  • Microangiopathic hemolytic anemiaHP:0001937
  • NephritisHP:0000123
  • Nephrotic syndromeHP:0000100
  • Pericardial effusionHP:0001698
  • Pleural effusionHP:0002202
  • ProteinuriaHP:0000093
  • Renal insufficiencyHP:0000083
  • Skin rashHP:0000988
  • ThrombocytopeniaHP:0001873

Occasional (29-5%)(21)

  • Abdominal distentionHP:0003270
  • Abdominal painHP:0002027
  • Abnormality of the nervous systemHP:0000707
  • Abnormality of the respiratory systemHP:0002086
  • ArthralgiaHP:0002829
  • ArthritisHP:0001369
  • AscitesHP:0001541
  • Dark urineHP:0040319
  • Discoid lupus rashHP:0007417
  • DyspneaHP:0002094
  • HeadacheHP:0002315
  • HemiplegiaHP:0002301
  • Lupus anticoagulantHP:0025343
  • Malar rashHP:0025300
  • Muscle weaknessHP:0001324
  • Oral ulcerHP:0000155
  • PsychosisHP:0000709
  • Reduced consciousnessHP:0004372
  • SeizureHP:0001250
  • Systemic lupus erythematosusHP:0002725
  • VomitingHP:0002013

Very rare (<4-1%)(8)

  • AlopeciaHP:0001596
  • Antineutrophil antibody positivityHP:0003453
  • Chest painHP:0100749
  • Cognitive impairmentHP:0100543
  • DiarrheaHP:0002014
  • Language impairmentHP:0002463
  • MyositisHP:0100614
  • Raynaud phenomenonHP:0030880