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Immune-mediated thrombotic thrombocytopenic purpura

ORPHA:93585 · Clinical subtype · Subtype of disorder

HPO 表現型（共 41 項）

Very frequent (99-80%)(4)

  • Anti-ADAMTS13 antibody positivityHP:6000462
  • Microangiopathic hemolytic anemiaHP:0001937
  • PurpuraHP:0000979
  • ThrombocytopeniaHP:0001873

Frequent (79-30%)(25)

  • Abdominal painHP:0002027
  • ArthralgiaHP:0002829
  • ComaHP:0001259
  • ConfusionHP:0001289
  • Decreased circulating haptoglobin concentrationHP:0020181
  • DiarrheaHP:0002014
  • DyspneaHP:0002094
  • FatigueHP:0012378
  • FeverHP:0001945
  • HeadacheHP:0002315
  • HematuriaHP:0000790
  • HyperbilirubinemiaHP:0002904
  • Increased circulating lactate dehydrogenase concentrationHP:0025435
  • Increased circulating troponin I concentrationHP:0410173
  • Intestinal ischemiaHP:0033404
  • Low back painHP:0003419
  • Muscle weaknessHP:0001324
  • MyalgiaHP:0003326
  • NauseaHP:0002018
  • ProteinuriaHP:0000093
  • ReticulocytosisHP:0001923
  • SchistocytosisHP:0001981
  • SeizureHP:0001250
  • StrokeHP:0001297
  • Unconjugated hyperbilirubinemiaHP:0008282

Occasional (29-5%)(12)

  • Abnormal EKGHP:0003115
  • Acute kidney injuryHP:0001919
  • AphasiaHP:0002381
  • ArrhythmiaHP:0011675
  • Cardiogenic shockHP:0030149
  • Chest painHP:0100749
  • Congestive heart failureHP:0001635
  • DiplopiaHP:0000651
  • Elevated circulating creatinine concentrationHP:0003259
  • Increased blood urea nitrogenHP:0003138
  • Myocardial infarctionHP:0001658
  • Sudden cardiac deathHP:0001645