← 返回搜尋

Neuroleptic malignant syndrome

ORPHA:94093 · Disease · Disorder

HPO 表現型（共 54 項）

Very frequent (99-80%)(6)

  • Abnormal autonomic nervous system physiologyHP:0012332
  • Extrapyramidal muscular rigidityHP:0007076
  • FeverHP:0001945
  • HyperhidrosisHP:0000975
  • MutismHP:0002300
  • Reduced consciousnessHP:0004372

Frequent (79-30%)(11)

  • DroolingHP:0002307
  • DysphagiaHP:0002015
  • Elevated circulating creatine kinase activityHP:0003236
  • Excessive salivationHP:0003781
  • FatigueHP:0012378
  • HypertensionHP:0000822
  • Increased total leukocyte countHP:0001974
  • Metabolic acidosisHP:0001942
  • Muscle spasmHP:0003394
  • TachycardiaHP:0001649
  • TremorHP:0001337

Occasional (29-5%)(33)

  • Acute kidney injuryHP:0001919
  • AgitationHP:0000713
  • AnxietyHP:0000739
  • ArrhythmiaHP:0011675
  • Aspiration pneumoniaHP:0011951
  • ChoreaHP:0002072
  • ComaHP:0001259
  • DehydrationHP:0001944
  • DeliriumHP:0031258
  • Elevated circulating alkaline phosphatase concentrationHP:0003155
  • Elevated circulating hepatic transaminase concentrationHP:0002910
  • EncephalopathyHP:0001298
  • HyperkalemiaHP:0002153
  • HypernatremiaHP:0003228
  • HyperphosphatemiaHP:0002905
  • Hypertensive crisisHP:0100735
  • HyperuricemiaHP:0002149
  • HypocalcemiaHP:0002901
  • HypomagnesemiaHP:0002917
  • HyponatremiaHP:0002902
  • HypotensionHP:0002615
  • Increased circulating lactate dehydrogenase concentrationHP:0025435
  • MyoglobinuriaHP:0002913
  • Nasogastric tube feedingHP:0040288
  • NauseaHP:0002018
  • Oculogyric crisisHP:0010553
  • ProteinuriaHP:0000093
  • Pulmonary embolismHP:0002204
  • RhabdomyolysisHP:0003201
  • RigorsHP:0025145
  • ThrombocytosisHP:0001894
  • Urinary incontinenceHP:0000020
  • VomitingHP:0002013

Very rare (<4-1%)(4)

  • BradycardiaHP:0001662
  • HypothermiaHP:0002045
  • SepsisHP:0100806
  • ThrombocytopeniaHP:0001873