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Acute adrenal insufficiency

ORPHA:95409 · Clinical syndrome · Disorder

HPO 表現型（共 44 項）

Obligate (100%)(2)

  • Decreased circulating cortisol levelHP:0008163
  • Primary adrenal insufficiencyHP:0008207

Very frequent (99-80%)(14)

  • Abdominal painHP:0002027
  • AnorexiaHP:0002039
  • AutoimmunityHP:0002960
  • ConstipationHP:0002019
  • DiarrheaHP:0002014
  • Failure to thriveHP:0001508
  • FatigueHP:0012378
  • Hyperpigmentation of the skinHP:0000953
  • HypotensionHP:0002615
  • HypovolemiaHP:0011106
  • Increased circulating ACTH levelHP:0003154
  • Muscle weaknessHP:0001324
  • Nausea and vomitingHP:0002017
  • Weight lossHP:0001824

Frequent (79-30%)(16)

  • Androgen insufficiencyHP:0008226
  • Decreased circulating aldosterone concentrationHP:0004319
  • Decreased urinary potassiumHP:0012364
  • HyperkalemiaHP:0002153
  • Hyperkalemic metabolic acidosisHP:0005976
  • HyperuricemiaHP:0002149
  • HypoglycemiaHP:0001943
  • HyponatremiaHP:0002902
  • HypotoniaHP:0001252
  • Increased circulating renin concentrationHP:0000848
  • Normocytic anemiaHP:0001897
  • Orthostatic hypotensionHP:0001278
  • Recurrent acute respiratory tract infectionHP:0011948
  • Renal insufficiencyHP:0000083
  • Renal salt wastingHP:0000127
  • SeizureHP:0001250

Occasional (29-5%)(12)

  • Adrenal hypoplasiaHP:0000835
  • ArthralgiaHP:0002829
  • Decreased female libidoHP:0030018
  • Delayed pubertyHP:0000823
  • Dry skinHP:0000958
  • HypercalcemiaHP:0003072
  • Myocardial infarctionHP:0001658
  • Salt cravingHP:0030083
  • Sparse axillary hairHP:0002215
  • StrokeHP:0001297
  • VertigoHP:0002321
  • VitiligoHP:0001045