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Stevens-Johnson syndrome/toxic epidermal necrolysis spectrum

ORPHA:95455 · Disease · Disorder

HPO 表現型（共 64 項）

Very frequent (99-80%)(5)

  • Abnormal blistering of the skinHP:0008066
  • Conjunctival hyperemiaHP:0030953
  • FatigueHP:0012378
  • FeverHP:0001945
  • Inflammatory abnormality of the skinHP:0011123

Frequent (79-30%)(22)

  • Abnormal bronchus morphologyHP:0025426
  • Abnormality of the pharynxHP:0000600
  • AcantholysisHP:0100792
  • AnemiaHP:0001903
  • AnorexiaHP:0002039
  • AnxietyHP:0000739
  • Atypical scarring of skinHP:0000987
  • ConjunctivitisHP:0000509
  • CoughHP:0012735
  • Elevated circulating hepatic transaminase concentrationHP:0002910
  • Genital blisteringHP:0031464
  • HeadacheHP:0002315
  • Hyperpigmentation of the skinHP:0000953
  • Keratoconjunctivitis siccaHP:0001097
  • MyalgiaHP:0003326
  • Oral mucosal blistersHP:0200097
  • Oral-pharyngeal dysphagiaHP:0200136
  • PharyngitisHP:0025439
  • Respiratory distressHP:0002098
  • RhinitisHP:0012384
  • Skin rashHP:0000988
  • Skin ulcerHP:0200042

Occasional (29-5%)(32)

  • Abdominal distentionHP:0003270
  • Abnormal penis morphologyHP:0000036
  • Abnormality of the anusHP:0004378
  • Abnormality of the larynxHP:0001600
  • Acute kidney injuryHP:0001919
  • Anterior uveitisHP:0012122
  • ChemosisHP:0012375
  • Corneal erosionHP:0200020
  • Decreased total neutrophil countHP:0001875
  • DepressionHP:0000716
  • DiarrheaHP:0002014
  • DysuriaHP:0100518
  • Gastrointestinal inflammationHP:0004386
  • Generalized abnormality of skinHP:0011354
  • HematuriaHP:0000790
  • Hypopigmentation of the skinHP:0001010
  • Increased tear productionHP:0031731
  • KeratitisHP:0000491
  • Moderate albuminuriaHP:0012594
  • Nail dystrophyHP:0008404
  • Oral synechiaHP:0010285
  • PhotophobiaHP:0000613
  • PneumoniaHP:0002090
  • Renal tubular epithelial necrosisHP:0008682
  • Respiratory failure requiring assisted ventilationHP:0004887
  • SymblepharonHP:0430007
  • TrichiasisHP:0001128
  • Vaginal drynessHP:0031088
  • Vaginal strictureHP:0025416
  • Visual lossHP:0000572
  • VulvodyniaHP:0030943
  • XerostomiaHP:0000217

Very rare (<4-1%)(5)

  • AnonychiaHP:0001798
  • BlindnessHP:0000618
  • Chronic lung diseaseHP:0006528
  • Intestinal perforationHP:0031368
  • SepsisHP:0100806