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Acromegaly
ORPHA:963 · Disease · Disorder
HPO 表現型（共 93 項）
Very frequent (99-80%)(27)
- Abnormality of the endocrine systemHP:0000818
- Acral overgrowthHP:0033794
- Anterior hypopituitarismHP:0000830
- ArthralgiaHP:0002829
- Broad footHP:0001769
- Broad foreheadHP:0000337
- Coarse facial featuresHP:0000280
- Cortical diaphyseal thickening of the upper limbsHP:0003859
- Deep palmar creaseHP:0006191
- Deep plantar creasesHP:0001869
- Elevated circulating growth hormone concentrationHP:0000845
- FatigueHP:0012378
- Full cheeksHP:0000293
- HyperhidrosisHP:0000975
- Joint swellingHP:0001386
- Large handsHP:0001176
- Long faceHP:0000276
- MacrodactylyHP:0004099
- MacroglossiaHP:0000158
- MacrotiaHP:0000400
- Mandibular prognathiaHP:0000303
- OsteoarthritisHP:0002758
- Pituitary growth hormone cell adenomaHP:0011760
- Seborrheic dermatitisHP:0001051
- Tapered fingerHP:0001182
- Thickened skinHP:0001072
- Wide noseHP:0000445
Frequent (79-30%)(32)
- Abnormality of the dentitionHP:0000164
- Abnormality of the menstrual cycleHP:0000140
- AnxietyHP:0000739
- AstheniaHP:0025406
- Broad jawHP:0012802
- Constrictive median neuropathyHP:0012185
- DepressionHP:0000716
- Diabetes mellitusHP:0000819
- DysmenorrheaHP:0100607
- Facial shape deformationHP:0011334
- Frontal bossingHP:0002007
- Generalized hirsutismHP:0002230
- Hoarse voiceHP:0001609
- HypertensionHP:0000822
- Hypogonadotropic hypogonadismHP:0000044
- Increased circulating insulin-like growth factor 1 concentrationHP:0030269
- Increased circulating prolactin concentrationHP:0000870
- Insulin resistanceHP:0000855
- KyphosisHP:0002808
- MigraineHP:0002076
- Multinodular goiterHP:0005987
- Palpebral edemaHP:0100540
- ParesthesiaHP:0003401
- Pituitary macroadenomaHP:0025693
- Prominent supraorbital ridgesHP:0000336
- Skin tagsHP:0010609
- Sleep apneaHP:0010535
- Spinal canal stenosisHP:0003416
- SynophrysHP:0000664
- Thick vermilion borderHP:0012471
- Type II diabetes mellitusHP:0005978
- Widely spaced teethHP:0000687
Occasional (29-5%)(34)
- Abnormal heart valve physiologyHP:0031653
- Acanthosis nigricansHP:0000956
- AcneHP:0001061
- Adrenal insufficiencyHP:0000846
- ArrhythmiaHP:0011675
- CholelithiasisHP:0001081
- Cranial nerve paralysisHP:0006824
- Cutis gyrata of scalpHP:0010541
- Decreased circulating HDL-C concentrationHP:0003233
- Decreased libidoHP:0046504
- Dental malocclusionHP:0000689
- DysuriaHP:0100518
- GalactorrheaHP:0100829
- Generalized hyperpigmentationHP:0007440
- HeadacheHP:0002315
- HydrocephalusHP:0000238
- HypersomniaHP:0100786
- HypertrichosisHP:0000998
- HypertriglyceridemiaHP:0002155
- Hypertrophic cardiomyopathyHP:0001639
- ImpotenceHP:0000802
- InfertilityHP:0000789
- Intestinal polypHP:0005266
- Mitral regurgitationHP:0001653
- MyalgiaHP:0003326
- Night sweatsHP:0030166
- OligomenorrheaHP:0000876
- OphthalmoplegiaHP:0000602
- Pituitary hypothyroidismHP:0008245
- Pituitary prolactin cell adenomaHP:0006767
- Restless legsHP:0012452
- Secondary amenorrheaHP:0000869
- Vertebral compression fractureHP:0002953
- Visual field defectHP:0001123