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Landau-Kleffner syndrome

ORPHA:98818 · Disease · Disorder

HPO 表現型（共 44 項）

Very frequent (99-80%)(8)

  • AphasiaHP:0002381
  • Continuous spike and waves during slow sleepHP:0031491
  • Interictal EEG abnormalityHP:0025373
  • Language impairmentHP:0002463
  • Loss of speechHP:0002371
  • SeizureHP:0001250
  • Speech apraxiaHP:0011098
  • Spoken word recognition deficitHP:0030391

Frequent (79-30%)(12)

  • Attention deficit hyperactivity disorderHP:0007018
  • Atypical behaviorHP:0000708
  • Autistic behaviorHP:0000729
  • Bilateral tonic-clonic seizure with generalized onsetHP:0025190
  • Developmental regressionHP:0002376
  • EEG with frontal focal spikesHP:0012015
  • EEG with generalized epileptiform dischargesHP:0011198
  • EEG with temporal focal spikesHP:0012018
  • Focal motor seizureHP:0011153
  • Generalized non-motor (absence) seizureHP:0002121
  • Social and occupational deteriorationHP:0007086
  • Speech articulation difficultiesHP:0009088

Occasional (29-5%)(22)

  • Aggressive behaviorHP:0000718
  • AnxietyHP:0000739
  • Atypical absence seizureHP:0007270
  • Bilateral tonic-clonic seizureHP:0002069
  • DepressionHP:0000716
  • Difficulty standingHP:0003698
  • Emotional labilityHP:0000712
  • Focal impaired awareness seizureHP:0002384
  • Focal myoclonic seizureHP:0011166
  • Frequent fallsHP:0002359
  • Gait ataxiaHP:0002066
  • Generalized clonic seizureHP:0011169
  • HyperactivityHP:0000752
  • ImpulsivityHP:0100710
  • Memory impairmentHP:0002354
  • MutismHP:0002300
  • Nocturnal seizuresHP:0031951
  • Non-convulsive status epilepticus without comaHP:0032671
  • Short attention spanHP:0000736
  • Sleep disturbanceHP:0002360
  • Slurred speechHP:0001350
  • Steppage gaitHP:0003376

Very rare (<4-1%)(2)

  • Autoimmune antibody positivityHP:0030057
  • Epileptic encephalopathyHP:0200134