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Cushing syndrome due to ectopic ACTH secretion

ORPHA:99889 · Disease · Disorder

HPO 表現型（共 83 項）

Very frequent (99-80%)(6)

  • Diabetes mellitusHP:0000819
  • Fatiguable weakness of proximal limb musclesHP:0030200
  • Increased circulating ACTH levelHP:0003154
  • Increased circulating cortisol levelHP:0003118
  • Increased urinary cortisol levelHP:0012030
  • Paradoxical increased cortisol secretion on dexamethasone suppression testHP:0003466

Frequent (79-30%)(34)

  • Abdominal obesityHP:0012743
  • Abnormal libidoHP:0031845
  • Abnormality of the cardiovascular systemHP:0001626
  • AcneHP:0001061
  • Adrenal hyperplasiaHP:0008221
  • AmenorrheaHP:0000141
  • AnxietyHP:0000739
  • AstheniaHP:0025406
  • Atypical behaviorHP:0000708
  • Bruising susceptibilityHP:0000978
  • Capillary fragilityHP:0025017
  • Decreased total eosinophil countHP:0031891
  • Decreased total lymphocyte countHP:0001888
  • Dorsocervical fat padHP:0025383
  • EcchymosisHP:0031364
  • Emotional labilityHP:0000712
  • HirsutismHP:0001007
  • Hyperpigmentation of the skinHP:0000953
  • HypertensionHP:0000822
  • ImmunodeficiencyHP:0002721
  • Increased body weightHP:0004324
  • Increased circulating androgen concentrationHP:0030348
  • Increased total leukocyte countHP:0001974
  • InsomniaHP:0100785
  • Intra-oral hyperpigmentationHP:0010284
  • Moon faciesHP:0500011
  • Muscle weaknessHP:0001324
  • OsteoporosisHP:0000939
  • PlethoraHP:0001050
  • Poor wound healingHP:0001058
  • Proximal amyotrophyHP:0007126
  • Striae distensaeHP:0001065
  • Thin skinHP:0000963
  • Truncal obesityHP:0001956

Occasional (29-5%)(26)

  • Abnormal lymph node morphologyHP:0002733
  • Abnormality of the respiratory systemHP:0002086
  • AnorexiaHP:0002039
  • Atypical pulmonary carcinoid tumorHP:0030446
  • DepressionHP:0000716
  • DiarrheaHP:0002014
  • FlushingHP:0031284
  • Impaired glucose toleranceHP:0040270
  • Malignant gastrointestinal tract tumorsHP:0006749
  • Memory impairmentHP:0002354
  • Myocardial infarctionHP:0001658
  • Neoplasm of the thymusHP:0100521
  • Neuroendocrine neoplasmHP:0100634
  • OligomenorrheaHP:0000876
  • Pancreatic endocrine tumorHP:0030405
  • Peripheral edemaHP:0012398
  • Psychotic episodesHP:0000725
  • PurpuraHP:0000979
  • Recurrent cutaneous fungal infectionsHP:0011370
  • Secondary amenorrheaHP:0000869
  • Skin ulcerHP:0200042
  • Sparse scalp hairHP:0002209
  • StrokeHP:0001297
  • Suicidal ideationHP:0031589
  • Vertebral compression fractureHP:0002953
  • Weight lossHP:0001824

Very rare (<4-1%)(15)

  • DementiaHP:0000726
  • HypergastrinemiaHP:0500167
  • Medullary thyroid carcinomaHP:0002865
  • Neoplasm of the stomachHP:0006753
  • Pancreatic adenocarcinomaHP:0006725
  • PancreatoblastomaHP:0100757
  • Panic attackHP:0025269
  • ParanoiaHP:0011999
  • Pedal edemaHP:0010741
  • PheochromocytomaHP:0002666
  • Prostate cancerHP:0012125
  • PsychosisHP:0000709
  • Pulmonary carcinoid tumorHP:0030445
  • Small cell lung carcinomaHP:0030357
  • Small intestine carcinoidHP:0006722

Excluded (0%)(2)

  • Large sella turcicaHP:0002690
  • Pituitary corticotropic cell adenomaHP:0008291